Major findings

Tangential migration

The tangential movement of neurons during development is a powerful source of neuronal diversity
Neurons that reach their final location in the brain from a distant origin, by tangential migration, acquire a novel cellular type. We have found tangential migrations all over the brain, everywhere we have tested. Cajal-Retzius cells, neurons of the olfactory cortex, even amygdalar neurons, all travel through the embryonic brain. This cellular movement is a rule of brain development, and no longer an exception.

Neural progenitor types

Many different types of neural stem cells generate the neurons of the neocortex
Regardless of the mammalian species under research, the progenitor populations giving rise to the neocortex are diverse and dynamic. From mouse to agouti and marmoset, we found that the germinative zone of the mammalian neocortex is widely heterogeneous and fearly similar across species. We also developed tools for combinatorial labelling of neural progenitors, useful for any vertebrate species.

Cortical scaffold cells

The cells providing instructions for cortical construction are missing in avian brains
Cajal-Retzius cells and subplate neurons are required to reach tangentially the developing neocortex. Once there, they provide essential cues for cortical formation and disappear when the job is complete. We tested the existence of this migraotry cells in the chick, that does not possess a neocortex. We found that the essential neurons for cortical development do not participate in the development of the avian brain, which suggest that the novel migration of these cells was a trigger for the origin of the neocortex.